Chemistry Professor Awarded $567,000 Three-Year Grant from National Science Foundation

Grant will allow Kenneth Mills to continue mentoring future leaders in STEM fields
April 5th, 2013 by 

Photo by: John Buckingham

Kenneth V. Mills, associate professor and chair of the chemistry department, has been awarded a $567,000 three-year grant from the National Science Foundation to study the chemical mechanism of protein slicing. Over the last decade, his research projects, which integrate student research participation, have enjoyed uninterrupted financial support from the National Science Foundation bringing in more than $1 million.

His current project is titled “Intein Structure and the Catalysis of Protein Splicing and Hedgehog Autoprocessing: An Integrated Research and Education Program.” Protein splicing is the means by which an intervening polypeptide, or intein, catalyzes its own removal from flanking polypeptides, or exteins. The research program will investigate how the activity of an intein from an extreme thermophile is influenced by its unusual structural stability, how the reaction is catalyzed, how intein activity is regulated, either by temperature or oxidation state, and how splicing is related to the autoprocessing of hedgehog-like domains.

The questions will be addressed by projects amenable to his undergraduates, in collaboration with Chunyu Wang and Saroj Nayak, a structural biologist and computational biologist, respectively, at the Rensselaer Polytechnic Institute.

The research program will have a transformational impact on the careers of Holy Cross research students, says Mills. Students will perform the experiments, present the results at national meetings and in peer-reviewed publications, and, through close mentoring, prepare to be future leaders in STEM (science, technology, engineering and mathematics). The biochemistry concentration will sponsor outreach in the community by hosting lectures aimed at broad audiences and by supporting the Science Ambassadors student outreach program. The program will broaden access to STEM by recruiting local students to the lab through the Worcester Pipeline Collaborative and by educational outreach at a Worcester elementary school.

During his 11 years at Holy Cross, Mills has mentored 35 undergraduate students in research, all but five for multiple years. His lab has produced 20 publications since 2001 with 19 undergraduate student coauthors, including 12 peer-reviewed publications, one technical note, and five review articles.

Of his 27 graduates through 2012, six have started Ph.D. programs in biochemistry or chemistry, five of whom are female. One has finished her Ph.D., another finished a master’s degree and works in industry, and the others are still candidates. Ten students have their medical or osteopathic medicine degrees or are in medical school and another is in a veterinary medicine program. Two are applying to health programs, five are in industry positions, one is a patent attorney and two are in teaching.

Mills’s students have made 33 presentations at national meetings of the American Society for Biochemistry and Molecular Biology or Protein Society, and all of his students in the past nine years have attended a national meeting.

“I attempt to provide research university-like opportunities within the supportive environment of a small liberal arts school,” Mills wrote in his proposal to NSF. “We have weekly group meetings, with everyone presenting their weekly work and one student presenting a research article or other assignment. They learn to troubleshoot, solve problems and analyze data. The students travel to national meetings and prepare their own posters. We have weekly departmental seminars, and I ensure that at least three a year are biochemical. … My students are my most important impact and their successes bring me the most pride of my professional work.”

A resident of Holden, Mass., Mills has been a member of the Holy Cross faculty since 2001. He earned his Ph.D. in chemistry and chemical biology at Harvard University. In 2005, Mills received the National Science Foundation’s CAREER grant for CAREER: Alternative Mechanisms of HINT Domain Autoprocessing: An Integrated Undergraduate Research and Education Program.” He is the co-chair of the biochemistry concentration and has served as a member of the Academic Affairs Council and the Curricular Review Steering Committee.

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This event is for Study Abroad Class of 2018 and Summer...
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
8/31/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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MPE Training Session
9/1/2017
Office of Multicultural Education
Henry M. Hogan Campus Center 320
Open to Campus Community Only
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/1/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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MPE Training
9/2/2017
Office of Multicultural Education
Henry M. Hogan Campus Center 320
Open to Campus Community Only
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/2/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/3/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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Latinidad Identidad
9/4/2017
Office of Multicultural Education
Henry M. Hogan Campus Center 401
Open to Campus Community Only
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Study Abroad General Information Session
9/4/2017
Study Abroad
Kimball Hall Seelos Theater
Open to Campus Community Only
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MPE Meeting
9/4/2017
Office of Multicultural Education
Henry M. Hogan Campus Center 320
Open to Campus Community Only
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/4/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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BSU Gathering
9/5/2017
Office of Multicultural Education
Henry M. Hogan Campus Center 402(03)
Open to Campus Community Only
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/5/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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Latinidad Identidad
9/6/2017
Office of Multicultural Education
Henry M. Hogan Campus Center 401
Open to Campus Community Only
See More >>


Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/6/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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Study Abroad Fair
9/7/2017
Study Abroad
Henry M. Hogan Campus Center Ballroom & 328
For Class of 2020 interested in studying abroad. Returnees...
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/7/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
See More >>


Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/8/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
See More >>


Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/9/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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Workshop on Teaching Statistics using R and RStudio
9/9/2017
Mathematics and Computer Science
Swords Hall 321
Open to Campus Community Only
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/10/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/11/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/12/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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MPE Information Session
9/13/2017
Office of Multicultural Education
Henry M. Hogan Campus Center 320
Open to Campus Community Only
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/13/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
See More >>


Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/14/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/15/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
See More >>


Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/16/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
See More >>


Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/17/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
See More >>


Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/18/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
See More >>


Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/19/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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Creating an Inclusive Campus: Skills and Practice
9/20/2017
Office of Diversity and Inclusion
Henry M. Hogan Campus Center 402(03)
This workshop will take diversity and inclusion from theory to...
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Career Fair
9/20/2017
Center for Career Development
Henry M. Hogan Campus Center 320
Open to Campus Community Only
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Career Fair
9/20/2017
Center for Career Development
Henry M. Hogan Campus Center 305
Open to Campus Community Only
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/20/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
See More >>


Career Fair
9/20/2017
Center for Career Development
Henry M. Hogan Campus Center Ballroom & 328
Open to Campus Community Only
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Career Fair
9/20/2017
Center for Career Development
Henry M. Hogan Campus Center 304
Open to Campus Community Only
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Career Fair
9/20/2017
Center for Career Development
Henry M. Hogan Campus Center Suite B/C - 4th Fl
Open to Campus Community Only
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Career Fair
9/20/2017
Center for Career Development
Henry M. Hogan Campus Center Suite A - 4th Fl
Open to Campus Community Only
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/21/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
See More >>


Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/22/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/23/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/24/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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GE Meet & Greet Session
9/25/2017
Center for Career Development
Henry M. Hogan Campus Center 304(05)
Come meet with GE to learn more about their internship program.Selected...
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/25/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
See More >>


Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/26/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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GE On-Campus Recruiting
9/26/2017
Center for Career Development
Henry M. Hogan Campus Center 404
Visit Crusader Connections to learn more about opportunities at GE...
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Nielsen Meet & Greet
9/27/2017
Center for Career Development
Henry M. Hogan Campus Center 406
Meet & Greet to learn about the Nielsen Company and finance internships...
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/27/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
See More >>


Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/28/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/29/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
See More >>


Stickwork: Patrick Dougherty, "Just Off the Beaten Track," 2016
9/30/2017
Arts Transcending Borders (ATB)
Lawn by Linden Lane
In September 2016, Arts Transcending Borders (ATB), in association with the Cantor...
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National Depression Screening Day
10/3/2017
Counseling Center
Henry M. Hogan Campus Center Lobby Table 5
Open to Campus Community Only
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National Depression Screening Day
10/3/2017
Counseling Center
Henry M. Hogan Campus Center Lobby Table 4
Open to Campus Community Only
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National Depression Screening Day
10/3/2017
Counseling Center
Henry M. Hogan Campus Center Lobby Table 3
Open to Campus Community Only
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National Depression Screening Day
10/3/2017
Counseling Center
Henry M. Hogan Campus Center Lobby Table 2
Open to Campus Community Only
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